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All Dentistry

by Stefan Neumeyer, MUDr, – Germany

“In order to be successful with any dental procedure, the biofilm must first be destroyed and removed. We have extensively evaluated HYBENX® Oral Tissue Decontaminant in a wide variety of restorative procedures for removing biofilm. This includes general prophylaxis, cavity preparations, orthodontia fixtures, surgical and non-surgical periodontology, and advanced peri-implantitis cases. We now use HYBENX® Solution and Gel throughout our practice.”

General Dental Infections

by Samuel Wexler, DDS, – IL, USA

“At first, I thought it was hocus pocus and I didn’t believe it. Finally, there is something that works instantly in treating dental infections such as Necrotizing Ulcerative Gingivitis.”

Restorative Dentistry

by Matthew Holyoak, BDS, Dip Rest Dent, MSc Rest Dent (RCS Eng) – UK

“The miracle cure for Perio.”

Periodontology

by Patrick A. Gaspard, DDS, MS – MN, USA

“We have used the HYBENX® Brand family of products in our practice for years, primarily for treatment of canker sores, periodontal pockets, and peri-implantitis.

For canker sores, we first apply a topical anesthetic, followed by the HYBENX Treatment.

In periodontal therapy, we use it as an adjunct in scaling and root planing (SRP). Local anesthetic was originally used to provide comfort, but lately we simply apply and remove HYBENX first, prior to SRP, to relieve discomfort. Plus, the prior application of HYBENX seems to make the SRP easier by helping loosen the calculus o the root surface. Inflammation seems to be reduced by the end of the procedure. Use of HYBENX seems to reduce pain during and after the procedure and the greater the inflammation, the greater the pocket reduction on follow up examination.”

Aphthous ulcers

by Suzanne M. Ebert, D.M.D. – FL, USA

“I have used the HYBENX® Technology products for years for aphthous ulcer treatments. One treatment is usually sufficient for most cases. I have yet to retreat the same ulcer and my patients report immediate permanent pain relief with total resolution of symptoms within about 20 minutes.”

Periodontology

by Ervin G. Savord, D.D.S. – USA

“In addition to years of success using HYBENX® Solution for aphthous ulcers, we use it extensively in periodontal procedures. After scaling and root planing, I instill the product for 30-45 seconds and remove with rinse/aspiration. When patients return, I find a majority have a significant reduction in pocket depth. The tissue around the tooth looks healthier and in some cases loose teeth have actually tightened up. In pockets of 5-7mm or greater I have seen pocket reductions of 3-4 mm after initial treatment. Repeated treatment gives reductions to pockets of 2-3mm.”

Periodontology

by James E. Black, D.D.S. – USA

“We routinely use HYBENX® Solution in periodontal pockets. We thoroughly root plane the pocket areas and then instill HYBENX into the pocket with a blunt-ended syringe needle. After about 30 seconds, depending upon the extent of the lesion, we rinse thoroughly with water aspiration.  We will often see a 3mm pocket reduction, less tissue inflammation, and a major reduction in overall pain.”

Periodontology

by Dr. Mary O’Dea, B.B.S., N.U. I., MClin Dent (Periodontology), EFP Cert (Periodontology)

“HYBENX® Oral Tissue Decontaminant has revolutionized my periodontal practice and I can’t imagine working without this product. I have worked with the product in periodontal therapy since 2010. I have many cases that show impressive bone remineralization and periodontal charting that shows good pocket reduction.”

Copyright © 2025 EPIEN Medical, Inc

EPIEN Medical, Inc. (Headquarters)
4225 White Bear Parkway
Suite 600
Saint Paul, MN 55110-3389 USA
Telephone: +1.651.653.3380
Contact US Headquarters
LocaGold s.r.l.
via Copernico ,27, 1 - 37135 Verona
Tel. +045/8250391
Contact European Headquarters
HYBENX® Oral Tissue Decontaminant is approved as a Class 1 medical device in the European Union and Canada. HYBENX® Oral Tissue Decontaminant is available to dental professionals as an adjunctive focal irrigant intended for the removal of dental plaque biofilm.